Designing the Future of Medicine: an Artificial Red Blood Cell

Built to Optimize Traditional Functions and Enable Proactive Diagnosis and Treatment of Infections

My Proposal: Artificial Red Blood Cell

More specifically, polyethylene glycol-polylactic acid copolymer nanocapsule encapsulating polyhemoglobin-superoxide dismutase-catalase-carbonic anhydrase, Apabetalone, the chemical inhibitor of CD47-SIRPα, Cyclodextrin-statin, Aliskiren and Midodrine. The nanocapsule’s surface is configured with polyethylene glycol, oxLDL, tissue plasminogen activator, various antibodies, bradykinin receptors and renin receptors.

TLDR

Principles

Quick Information

PolyHb-SOD-CAT-CA — Oxygen and Carbon Dioxide Transport + Antioxidant Mechanism

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Visualization of the interactions of O₂ and CO₂ with a traditional tissue cell. Source

Polyethylene Glycol — Evading the RES

Process of Opsonization. Opsonin (blue), Nanoparticle (Red) and Phagocyte (Yellow). Source
Example of a PEG-coated gold nanoparticle. Source

Polyethylene Glycol — Polylactic Acid Copolymer Membrane

Proactive Diagnosis and Treatment of Atherosclerosis

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Oversimplified diagram of reverse cholesterol transport. Cholesterol (blue), HDL (green). Source

Regulating Blood Pressure

Diagnosis to Treatment of Infections

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Solving Blood Incompatibility

Nanocapsule Production

Diagram of each step of emulsion. Source
Another representation of the process of emulsion solvent evaporation. Source

Final Thoughts

Thanks for Reading!

15-year-old Nanotechnology enthusiast whose mission is to use technology to solve real-world problems.